Kew S, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, et al
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Tua hyperphosphorylation: ROS and RNS contribute to the abnormal phosphorylation of Tua proteins, lose capacity to bind to brain cell microtubule, and bind to each other, tying themselves in knots, leading to neurofibrillary tangles (NFTs)
doi:10.3390/jcm14113812 10.Jastreboff AM, Ryan DH, Bays HE, et al
By simultaneously activating GLP-1, GIP, and glucagon receptors, it allows researchers to investigate receptor cross-talk, intracellular cascades, and their role in glucose regulation, lipid metabolism, and energy homeostasis
Cirulli, Int