Aside from AsPC-1, LUNA-18 exhibited significant cytotoxic activity (IC50=0.17-2.9nM) against cell lines with KRAS gene mutations, such as LS180 (colorectal cancer, KRASG12D), GSU (gastric cancer, KRASG12D), NCI-H441 (non-small cell lung cancer, KRASG12V), NCI-H2122 (non-small cell lung cancer, KRASG12C), and MiaPaCa-2 (pancreatic cancer, KRASG12C)
Metabolic rate adjustments begin reverting
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A 2025 meta-analysis in Scientific Reports found that GLP-1 receptor agonists reduced body weight, BMI, and insulin resistance in women with PCOS, although nausea, vomiting, and dizziness were more common
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5C we observed a densely packed mass for the denatured trial as opposed to a less densely packed sample within the non-denatured trials (Fig