Notably, comparative angiogenic profiling through CD31 immunohistochemistry revealed a dose-dependent increase in microvascular density in the BPC157-treated rodent skeletal muscle contusion model groups (muscle injury model: 1.7 0.4 vessels vs
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Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization
BPC-157 is a synthetic pentadecapeptide derived from gastric juice protein sequence, studied for inflammatory signalling, cytoprotection, and tissue repair across tendon, ligament, muscle, and GI models