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2024 from: Stice, Eric et al

It was developed by modifying the natural GLP-1 molecule to: Promote albumin binding: This extends circulation time by slowing renal clearance Resist DPP-4 degradation: Structural modifications protect it from the enzyme that breaks down natural GLP-1 Semaglutide selectively binds to and activates the GLP-1 receptor, triggering the same beneficial downstream effects as natural GLP-1but with sustained activity over days rather than minutes

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People who took the drug lost a significant amount of weight, thus reducing their risk of cardiac complications, but experts say that the amount of improvement suggests the drugs heart effects likely occurred through mechanisms besides weight loss alone

Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses

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