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The medication may be allowed to reach room temperature before administration if stored under refrigeration, as cold injections may be more painful and could potentially affect absorption kinetics

18 CeroveckiT.BojanicI.BrcicL.RadicB.VukojaI.SeiwerthS.et al (2010)

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When this happens, it creates a backup that can damage the kidneys, create bladder stones or lead to bladder infections