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Should be used with caution in individuals with peripheral vascular disease, as it may worsen symptoms

While the molecular weight of semaglutide (approximately 4,113 Da) might theoretically limit passage into breast milk, this has not been confirmed in human studies

247 Disruption of mitophagy may result in the accumulation or cytosolic release of damaged mtDNA, which functions as a damage-associated molecular pattern (DAMP) and activates inflammatory pathways involved in pancreatic necrosis and inflammation

It is not known if Semglee is safe and effective in children with type 2 diabetes

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