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They also promise to reduce the overall number of therapies requiring PA (one pledge is to cut a third of PA requirements by 2026) ( [42] ) ( [63] )
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But these drugs are only moderately effective, researchers said
10.1128/CMR.00338-20 407 SouzaP
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News provided by Eli Lilly and Company Dec 11, 2025, 06:45 ET In TRIUMPH-4, participants with obesity and knee osteoarthritis taking retatrutide 12 mg lost an average of 28.7% of their body weight at 68 weeks Retatrutide reduced WOMAC pain scores by up to an average of 4.5 points (75.8%) and significantly improved measures of physical function, with more than 1 out of 8 retatrutide-treated patients completely free from knee pain at the end of the trial Seven additional Phase 3 trials evaluating the investigational once-weekly treatment in obesity and type 2 diabetes are expected to complete in 2026 INDIANAPOLIS, Dec
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