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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects

2024, pubmed.ncbi.nlm.nih.gov/38231320/#:~:text=However%2C%20the%20top%20two%20ranked, Baltaci, Davut, et al

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In addition, It is well known that melasma is a frequent relapsing pigmentary disorder and treatment of melasma is a life long treatment Cassiano and colleagues

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