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That same mechanism is what creates the absorption problem: any oral medication depends on reaching your small intestine on a predictable schedule to be absorbed properly

Anecdotal reports suggest UTI risk is highest during the initial weeks and during dose increases, which aligns with when GI side effects (and therefore dehydration risk) are most pronounced

With the latter, this may accelerate hair thinning in those with androgenic alopecia, as weve discussed

However, patients should distribute fluid intake throughout the day rather than consuming large volumes at once, and consider reducing intake 23 hours before bedtime to minimize nocturia

NAC can be taken on an empty stomach, but if you have a sensitive digestive system, taking it with a small snack or meal can help prevent mild discomfort