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In the original 2017 mouse study, FOXO4-DRI was reported as well-tolerated in vivo at the dosing used

Scientists often compare Retatrutide with related investigational compounds such as Semaglutide, Tirzepatide, and Survodutide to better understand differences in receptor selectivity, signaling bias, pharmacodynamic characteristics, and experimental outcomes

The Morris Water Maze task served as the primary behavioral assessment, involving 8 days of training with 5 trials per day