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MDSCs also actively recruit other immunosuppressive cells, such as Tregs and tumor-associated macrophages (TAMs), which amplify the immunosuppressive network in the TME [23]

For the tumour allograft model, Gclc f/f Rosa26 creERT2 MMTV-PYMT mice were euthanized and autochthonous tumours were collected, cut into 8 mm 3 fragments and cryopreserved in liquid nitrogen

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Animal studies show dandelion root extract can reduce hepatic fat accumulation, though human trials remain limited