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Companies discontinued agents such as liraglutide and Albiglutide, while the approval of combination therapies such as liraglutide/insulin degludec highlights the role of GLP-1 receptor agonists in diabetes and obesity management (23)(25)

In the meantime, dermatology professionals may wish to consider GLP-1s for patients with refractory HS, particularly when weight loss and metabolic improvements could enhance disease outcomes

GSH has been shown to act as a reductive co-substrate for GPX4, inducing GPX4 inactivation and thereby triggering ferroptosis in tumour cells

Intriguingly, other studies report no change in fibroblast responsiveness with age [165]

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