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Simultaneously, it plays a role in sexual function via pathways in the hypothalamus and midbrain

Studies in ovariectomized mice showed that estrogen replacement increased GLP-1 release from both intestinal L-cells and pancreatic alpha-cells

Recent evidence of microglial expression of the TJ protein, claudin-5, at the vasculature was observed in a systemic lupus erythematosus (SLE) mouse model (Haruwaka et al., 2019)

If youre trying to understand your progress on tirzepatide, these physician-reviewed guides may also help: If youve been taking tirzepatide consistently and your weight has not changed for several weeks, scheduling a follow-up appointment may help identify why progress has slowed

The slow titration schedule exists specifically to minimize these effects

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