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This tachyphylaxis of gastric emptying is best documented for long-acting GLP-1 receptor agonists, where short-acting agents produce large, sustained emptying delays while long-acting agents produce an emptying delay that wanes with continued dosing

Baseline measurements before starting, periodic monitoring during use, and follow-up assessment after cycling off provide data points that can reveal individual response patterns

[42] Low maternal vitamin B 12 , defined as serum concentration less than 148 pmol/L, increases the risk of miscarriage, preterm birth and newborn low birth weight

The same holds true for people who suspect they have B12 deficiency, and already start to supplement with oral B12

Overall, B-12 injections are relatively safe with no significant side effects, but below are unknown incidents that may occur