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Since treatment with Hex, a hippocampal ligand of PPAR (9), elicited both AMPA-dependent and NMDA-dependent postsynaptic calcium currents in the hippocampi of 5XFAD mice (Figure 3, C and D), we next investigated whether global knockdown or hippocampus-specific deletion of PPAR interfered with Hex-induced postsynaptic calcium currents in 5XFAD mice