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In a Phase 2 randomised controlled trial published in The New England Journal of Medicine (Jastreboff et al., 2023), participants without type 2 diabetes receiving the highest doses of retatrutide achieved mean body weight reductions of approximately 24% over 48 weeks

Study 1 included participants who were unwilling or unable to use PAP therapy

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Tirzepatide is not available over the counter

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Funding Open access funding provided by HUN-REN Biological Research Centre, Szeged