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Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

Youn yaam artlar, olumsuz evre koullar, ilenmi besinler, giderek artan stres faktrleri (trafik, i ilikileri, hzl yaam) dzenli olarak dengeli bir diyet uygulanmasn zorlatrabilir

These contraindications are based on safety concerns identified in animal studies or lack of adequate human safety data in these populations

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### **Office setting and commercial payers** When the procedure is performed in an office-based setting, the lens may be billed separately if covered by the payer