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We note that although the chondroprotective effects of metformin was clearly attenuated in Nrf2 KO mice, micro-CT analysis revealed some variability in trabecular bone parameters, including occasional increases in subchondral trabecular bone amounts in Nrf2 KO OA mice (Fig
For those planning a pregnancy, medical guidelines in 2026 suggest a two-month washout period to ensure the medication is fully eliminated
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