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Braidy, N
Mechanistically, low doses increased AR binding to half-site-containing enhancers, whereas AR was lost from canonical AREs
Covalent binding increases with APAP dose and with P-450 activity and the increase is non-linear
A serum APAP concentration (measured at least 4 hours after ingestion) resulting in a value above the lower line of the nomogram necessitates a full course of NAC therapy (eg, standard oral loading dose of 140 mg/kg of NAC followed by 70 mg/kg every 4 hours for 17 oral doses) be delivered
Targeting the vulnerability to NAD(+) depletion in B-cell acute lymphoblastic leukemia