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The mechanism of action is very imbalanced, since while it has a comparable GIP receptor binding affinity to native GIP, the affinity to the native GLP-1 receptor is five times lower [20, 21]

Bitter melon also known as karela is a tropical and subtropical vine belonging to the Cucurbitaceae family, extensively cultivated in Asia, Africa and the Caribbean

GIP and GLP- 1 have opposing effects on glucagon release, despite their similarities

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