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Side effects that are uncommon or possibly serious may include sweating, tinnitus, shakes, rash, stomach and/or muscle pain, vision changes and/or symptoms of glaucoma

Symptoms of HFpEF can include shortness of breathoften with exertionfatigue, and swollen ankles

Unlike semaglutide, Zepbound also targets glucose-dependent insulinotropic polypeptide (GIP) receptors in the stomach and brain

FDA staff's own briefing document, posted publicly ahead of the meeting as part of the docket, proposes that TB-500 (free base) and TB-500 acetate not be added to the list, citing incomplete physicochemical characterization, a lack of evidence of effectiveness for wound healing (including an in-vitro fibroblast study in which TB-500 reportedly did not induce wound healing), and insufficient nonclinical and clinical safety data

Storage advice Store in a cool, dry and dark place

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