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The designed system destabilized in endosome upon cleavage of cis-aconityl at low pH, leading to endosomal disruption with regenerated parent polycation and releasing mono-siRNA to circumvent immune system
Biol Pharm Bull 36:399406 Ke X, Xiong Y, Yu B et al (2022) Mollugin induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in hepatoma cells
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2.4 Gene Expression Modulation: Genomic studies (e.g., Pickart et al., 2012) reveal GHK-Cu resets over 4,000 genes to a youthful state, upregulating repair genes and downregulating inflammatory ones, a unique epigenetic effect
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Prepare and inject each peptide separately, even if using the same injection site
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