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Until then, the risks of unofficial supply far outweigh any potential benefit

For postmenopausal women whose cardiovascular risk has increased significantly, this benefit adds meaningful weight to the case for GLP-1 therapy beyond weight management alone

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These pleiotropic effects likely contribute to the cardioprotective and cognitive-preserving actions of SGLT2 inhibitors, further supporting the concept that targeting mitochondrial dysfunction can concurrently benefit cardiovascular and neurological outcomes

Kenji Hara received Grant-in-Aid for Scientific Research (KAKENHI), Grant Number 23K10720 from Japan Society for the Promotion of Science (JSPS)

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