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Obesity reduced the anti-cancer effects of the antidiabetic adiponectin receptor agonist AdipoRon in diet-induced obese mice with orthotopic pancreatic cancer through a mechanism involving IGF-1, IGF-1R, and ERK1/2 signaling (5), indicating the importance of weight loss in combating pancreatic cancer in obese patients

Emsley, P

Aconite poisoning can cause low blood pressure, chest pain, increased or decreased heart rate, and irregular heart rhythm that can lead to cardiac arrest and death

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Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator