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Glucose-Dependent Insulinotropic Polypeptide (GIP): Secreted from K-cells in the proximal small intestine (duodenum and jejunum), GIP was the first incretin hormone to be discovered

Working with a registered dietitian can help create a personalized plan

Combine this with all the other factors conspiring to put the lost weight back on, and you can end up potentially becoming even fatter than they were to begin with

The structural synaptogenic effects new neural connections are believed to develop over 4-8 weeks of consistent use

John Horneff, suggested that this isnt necessarily a poisonous effect of the drug itself, but rather a consequence of the rapid weight loss and nutritional changes that often accompany GLP-1 use

These effects appear to be mediated through modulation of dopamine signaling in the mesolimbic reward system in animal models, potentially dampening the reinforcing properties of addictive substances