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It has been hypothesized that Sermorelin may provide a foundational hypothalamic-style signal, while Ipamorelin might act as a modulatory amplifier through the ghrelin receptor pathway
Placebo-controlled dose-ranging phase 2 study of subcutaneously administered LHRH antagonist cetrorelix in patients with symptomatic benign prostatic hyperplasia
Modified from Tschop et al
Brain Dev 33:512517 Sakai E, Yamanaka G, Kawashima H, Morishima Y, Ishida Y, Oana S, Miyajima T, Shinohara M, Saitoh M, Mizuguchi M (2013) A case of recurrent acute encephalopathy with febrile convulsive status epilepticus with carnitine palmitoyltransferase II variation
Tesamorelin increases IGF-1, which is exactly what we want for body composition and longevity, but it does require monitoring to ensure levels stay within optimal range
Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA et al (2018) N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E 2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
