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Administered as self-injections (e.g., subcutaneously in the abdomen), they start at low doses and titrate every four weeks based on responsee.g., from 0.25 mg to higher levels

(2) van der Klaauw A, Keogh J, Henning E, Stephenson C, Trowse VM, Fletcher P, Farooqi S

Subsequent pore formation following binding to cardiolipin may then facilitate entry of the oligomers into the intermembrane space, where they then gain access to much more cardiolipin present on the inner membrane

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It does not have a withdrawal effect, rebound pigmentation or abrupt darkening associated with the discontinuation of glutathione