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So afterwards the body doesnt go back into alignment

However, although GLP-1 receptor agonists are known to produce modest but statistically significant weight loss in patients with diabetes mellitus, our knowledge of how endogenous GLP-1 regulates food intake and body weight remains limited

You'll see articles that say "10-14% of patients get headaches on semaglutide" without distinguishing between: Positional headaches from CSF dynamics (this article's focus) Tension headaches from medication-induced stress or sleep disruption Migraine triggered or worsened by the medication Nausea-associated headaches (part of the GI symptom cluster) Dehydration headaches without a positional component Medication overuse headaches from treating the above These are mechanistically distinct

Choosing dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, or both, as add-ons to metformin: patient baseline characteristics are crucial