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To further validate these results, we analysed a subset of genes from the Met deprivation signature, which were among the most highly enriched by GSEA, in reprogramming tissues by quantitative PCR with reverse transcription (RTqPCR)

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These medications include proton pump inhibitors (which are sometimes prescribed for people with GERD), the gout medication colchicine, the diabetes drug metformin, and H2 blockers such as Pepcid