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Intracellular IGF-1 is mainly expressed as proIGF-1Ea, not mature IGF-1 Using RT-PCR analyses, we previously demonstrated that skeletal muscles, adipose tissues and liver of several mammalian species mainly expressed the IGF-1Ea isoform, which represents about 90% of IGF-1 transcripts 5
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Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012
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Cardiovascular morbidity and mortality associated with the metabolic syndrome
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