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It is most concentrated in cortical glial cells and microgliakey immune cells accounting for 10% of brain cells
By contrast, NAT2 is not evident until about 12 months after birth (ParienteKhayat et al., 1991)
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An APAP solution freshly-prepared by dissolving with heating acetaminophen (Sigma-Aldrich) in saline solution was administrated into mice by intraperitoneal injection at 300 mg/Kg
Rapid acetylators were competent in isoniazid acetylation but the drug was cleared less efficiently in the slow acetylator group, which resulted in elevated serum concentration and led to adverse neurologic side effects due to an accumulation of unmetabolized drug (Brockton et al., 2000)
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