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Improved Tolerability for Sensitive Users Users with pre-existing GI conditions or those who are highly sensitive to peptide-based therapies may find that lower doses let them access some of the drug's metabolic effects without triggering severe symptoms

"I just feel like an unlucky girl and wish I could take the medication

Phase 3 dose selection has not been publicly announced

The question, as with combining GLP-1 and GIP receptor activity, is whether adding glucagon receptor activity to GLP-1 receptor activity exceeds the glycaemic lowering and weight loss achieved with a GLP-1 RA alone (Ambury et al, 2018

Doctors might change this based on how well the patient is doing