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Benefits during the off period depend significantly on lifestyle factors

The magnitude of this effect for ipamorelin is not quantified in any published human study

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This concern is particularly relevant for patients with stricturing CD, in whom up to 50% develop fibrostenotic complications within 10 years of diagnosis (74)

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Known risk factors include, among others: the expected benefits and opportunities related to the collaboration and the companion diagnostics may not be realized or may take longer to realize than expected due to challenges and uncertainties inherent in product research and development