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As new agents emerge including GLP-1/glucagon co-agonists and small-molecule GLP-1R modulators we must stay grounded in evidence, mechanism, and equity

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Akkermansia Muciniphila : Promising results for insulin sensitivity Akkermansia Muciniphila As for Akkermansia Muciniphila , a bacterium claimed by trending supplement brand Pendulum to increase GLP-1 production, he says, Its a pretty promising microbe when it comes to insulin sensitivity, but Ive not seen any human clinical data about Akkermansia, GLP-1 production and weight loss. On its website, the company (which includes actress Halle Berry among its investors) links to animal research showing that Akkermansia Muciniphila increased GLP-1 production in mice on a high-fat diet

Nutritional Regulation : Adequate intake of lysine and vitamins (such as vitamin C and B6) is crucial for the optimal functioning of the biosynthetic pathway

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