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It has two major functions: DNA repair and redox regulation (Angkeow et al., 2002), and it is particularly important in neurons because they are highly susceptible to oxidative DNA damage (Copped, 2011)

Plant Cell 22 , 376391 (2010)

It plays a vital role in various bodily functions, particularly in protecting cells from oxidative stress and detoxifying harmful substances

This further resulted in disrupting mitochondrial functioning and enhanced ROS accumulation, enhancing lung cancer ferroptosis therapy [427]

M., Parkinsons disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Although current clinical treatments, including nonsteroidal anti-inflammatory drugs, glucocorticoids, and immunosuppressants, can alleviate symptoms, their long-term use is often associated with adverse effects such as gastrointestinal damage, hepatorenal dysfunction, and increased risk of infections, which significantly limit their clinical application (35)