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Mast cells are present adjacent to the neurons and glial cells in thalamus, hypothalamus, and leptomeninges and activate them by cell-to-cell contacts as well as by releasing inflammatory and neurotoxic mediators (Theoharides et al., 2013)

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

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Third, the one-week washout interval, although sufficient to reverse most clinical effects, may not completely eliminate slower-resolving mediators, potentially attenuating periodtoperiod contrasts

Dosages vary by formulation

Defer protocol in cases of acute infections until resolved