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Are compounded GLP-1s safe

Both the semaglutide and tirzepatide shortages that made compounding legally available were declared resolved in 2024 and 2025, the compounding wind-down deadlines have passed, and in April 2026 the FDA proposed closing the remaining legal pathway entirely

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While formal drug interaction studies are limited, AOD-9604 can often be safely combined with other therapies under proper medical supervision

If natural remedies aren't enough, you may consider using over-the-counter products like stool softeners (e.g., docusate sodium) or mild laxatives (e.g., polyethylene glycol)

Never mix semaglutide and insulin in the same syringe