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In some research contexts, higher doses have been explored, but those studies involve close medical monitoring that is a far cry from someone self-administering based on a chart they found in a Facebook group

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This paradigm realignment is reinforced by health-economic modeling: preventing one major adverse cardiovascular event (MACE) with a GLP-1RA over 5 years (number-needed-to-treat 56) costs less, on average, than treating the resultant myocardial infarction, heart-failure admission, or dialysis initiation [53]

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doi: 10.1038/s43018-025-01110-1