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The control of feeding behaviour by GLP-1 and exendin-4 has been explored in Zucker obese rats, resulting in a reduction in food intake, with exendin-4 being much more potent than GLP-1

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However, in murine models, exendin-4 demonstrates about 5,500-fold greater potency in improving glucose control, evidenced by the percentage fall in plasma glucose at 1 hour (87)

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It is worth mentioning that China's FDA said that the application for a marketing license for LIR injection for obesity or overweight indications had been accepted, which was the first time that the weight control indications of GLP-1R agonists have been accepted in China