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A 39-amino acid peptide like tirzepatide presents 38 peptide bonds, each one a potential cleavage site
26,27 Suggestive evidence of hemoglobin A1c-lowering being the cause of the reported worsening with GLP-1/GIP agonists can be derived by comparing the results of two recent retrospective cohort studies assessing retinopathy outcomes between subjects treated with GLP-1/GIP agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors
This slow up-titration is a recurring feature of incretin research and serves to reduce gastrointestinal effects
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