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The temperature of the fed-batch culture was maintained at 37 C

Avoid combining it with highly acidic or basic solutions, as this can compromise stability

Food remains in the gastric cavity for a prolonged period, which can physically stretch the stomach wall and irritate local nerve pathways

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The synthetic GLP-1 receptor agonists mimic this endogenous hormone but are modified to resist rapid enzymatic breakdown by dipeptidyl peptidase-4 (DPP-4), thereby extending their duration of action