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N Engl J Med 2016;375:323-334

Semaglutide (Ozempic, Wegovy, Rybelsus) Strengths: Strong evidence base with extensive clinical trial data Once-weekly dosing (injection) or daily (oral) Excellent glucose control and weight loss Proven cardiovascular and kidney benefits Widely available Considerations: Gastrointestinal side effects common initially Cost without insurance is significant Best for: Most patients seeking strong glucose control with weight loss