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Fer-1 operates as a ferroptosis inhibitor, predominantly through the scavenging of lipid peroxides
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Under normal physiological conditions, activation of the Keap1-NRF2 signaling pathway promotes the activation of System Xc - and the expression of GPX4 and accelerates cysteine glutamate transport, thereby clearing accumulated lipid peroxidation and inhibiting ferroptosis (86)
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