Unlike traditional single-pathway or dual-pathway incretin compounds, this molecule is structurally designed to activate GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors simultaneously
Am J Chin Med 2023;51:9971018
Interestingly, the STEP-8 study 22 revealed a higher incidence of psychiatric events with liraglutide 3 mg (15.0%) compared to semaglutide 2.4 mg (5.6%) and placebo (10.6%)
Even with the twice-daily needles and the initial queasiness, it was worth it
That's great news for the company, as the GLP-1 space is expected to expand rapidly over the next decade
From the LAG-1 AID time course, five genes were identified where their RNA level was dependent on LAG-1 at 4 hrs of auxin treatment, raising the possibility that they were direct/primary targets of LAG-1 activity