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While tirzepatide generally maintains its effectiveness over time, certain situations warrant a conversation with your healthcare provider about your treatment response

What happened Researchers presenting at ENDO 2026 in Chicago on June 13, 2026 found that adults with obesity who started a GLP-1 receptor agonist drugs like semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), liraglutide, or dulaglutide became noticeably less physically active after beginning treatment

VA launches trial of GLP-1 drugs to treat alcohol use disorder in veterans The Department of Veterans Affairs is launching a new clinical trial to test whether GLP-1 drugs used for weight loss and type 2 diabetes can treat alcohol use disorder in veterans

If approved, TRICARE beneficiaries pay a $38 copay for a 90-day supply through the TRICARE Pharmacy Home Delivery program

However, another study showed that the NK1R antagonist L822429 reduced progressive ratio responding for alcohol by P rats, but not by Wistar rats (Schank et al., 2013)

So those are some things that researchers are concerned about