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FIGURE 1 The Hgf/c-Met Axis Hepatocyte growth factor was originally discovered in in vitro experiments as a hepatocyte mitogen (Nakamura et al., 1984) for primary hepatocytes that promoted the cell motility of epithelial cells (Stoker et al., 1987)

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Compared with commonly used enzymes including pepsin, trypsin, neutral protease, acid protease, bromelain, and flavour protease etc., alkaline protease, as an endonuclease with broad specificity, the enzymatically digested plant protein peptides have the strongest inhibitory effect on -glucosidase, therefore, alkaline proteases are widely used to hydrolyze a variety of plant proteins (65, 66)

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