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The main cerebral target for THC is type-1 cannabinoid receptors (CB1R), which are widely expressed in the brain and regulate various functions including neurotransmitter release, neuro-astroglial communication, and cellular bioenergetic processes [29,30,31,32]
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4-Hydroxyestrogens are endogenous neuroestrogens that can strongly protect neurons against oxidative death by promoting p53 cytoplasmic localization
More recent studies with the Romanian population suggest that the polymorphism of the Ile105Val gene was associated with the risk of developing type 2 DM, but not with the risk of developing DN
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