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The impact of energy deprivation on the signaling pathways of erythrocytes was later disclosed in a mechanistic study: here, the authors demonstrated that removal of extracellular glucose and blockade of glycolysis by 2-deoxyglucose leads to fast depletion of cellular ATP
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[PMID: 8155868] PubMed record related to this compound for laboratory literature review
Studies using fluorescence microscopy and co-immunoprecipitation techniques have visualized this molecular displacement mechanism, confirming target engagement in senescent but not healthy cells
Dondelinger, Y
