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The piece opens with a quote from Tom Hildebrandt, PsyD

Wait at least 30 minutes before eating, drinking (even coffee), or taking other medications

They work by inhibiting enzymes known as cyclooxygenase (COX-1 and COX-2), which are responsible for producing prostaglandinsthe lipid compounds in the body that signal pain and trigger inflammatory responses

Heres how they compare: Note: While both options may cause gastrointestinal discomfort, oral GLP-1 drugs tend to have fewer severe side effects, especially when it comes to injection-related issues

Your dose-response curves will be skewed, your results will be weak or nonexistent, and your conclusions will be built on a faulty foundation

Healthcare professionals may consider checking orthostatic blood pressure and appropriate investigations (e.g., urea and electrolytes) if symptoms persist or dehydration is suspected