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In the gut-kidney axis, butyrate-mediated activation of the PI3K/AKT/mTOR signaling pathway via free fatty acid receptor 2 (FFAR2) enhances GPx and SOD activities while reducing MDA levels, thereby alleviating oxidative stress in diabetic nephropathy [72]
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For example, single cell RNA-seq analyses reveal that cardiac GLP-1Rs are expressed in some atrial and ventricular endothelial cells, and localised to the ventricular endocardium in mice
Yes, when used correctly
Meta-analysis of randomised trials comparing the effectiveness of miniaturised versus conventional cardiopulmonary bypass in adult cardiac surgery
The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation
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